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Scatter plots of the cumulative (A) and annualized (B) incidence rate of infective endocarditis (IE) plotted against the sample size (number of patients) of the individual studies14, 15, 16, 17, 18, 19, 20, 21, 22 (Spearman correlation coefficient=−0.80 and −0.73, P=0.010 and P=0.025, respectively).
