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. 2018 Jun 30;7(13):e006908. doi: 10.1161/JAHA.117.006908

Figure 8.

Figure 8

Left ventricular (LV) remodeling in Velvet mice with aortic valve dysfunction. Short‐axis end‐diastolic images from a control mouse (A) and from a Velvet mouse with severe aortic regurgitation (AR) and severe aortic stenosis (AS) (B). LV enlargement (C) and hypertrophy (D) were present at all ages in Velvet mice with moderate/severe AR or AS (Vel‐AR/AS), but not in Velvet mice with normal or mildly impaired valve function (Vel‐nl). LV ejection fraction (EF) remained normal in Velvet mice until 8 months of age, when ≈18% demonstrated severely decreased LVEF (P=not significant for all Vel‐AR/AS vs control, at all ages; E). Data are given as mean±SEM. EDV indicates end‐diastolic volume; RV, right ventricle. *P<0.025 vs age‐matched control.