Figure 7.

The mRNA expression levels of ENaC family members and NHE3 in the kidneys with each treatment. The mRNA expression in the kidneys of α‐ENaC (A), β‐ENaC (B), γ‐ENaC (C), and NHE3 (D) with a standard diet, a high‐salt diet, and DOCA/salt treatment, as measured by quantitative polymerase chain reaction. Gene expression was normalized to that of 18S rRNA and is expressed relative to that in control mice on a standard diet. Data are expressed as mean±SEM. n=6 to 8 per genotype and group. P<0.05 vs ^†standard diet, ^§high‐salt diet. DOCA indicates deoxycorticosterone acetate; ENaC, epithelial sodium channel; IEC‐MR‐KO, intestinal epithelial cell–specific mineralocorticoid receptor knockout; NHE3, sodium–hydrogen exchanger 3.