Table 3.

Effects of Low‐Salt Diet

	Control (n=7)	IEC‐MR‐KO (n=7)	P Value
Body weight, g	27.4±0.8	17.4±0.3	0.002
Water intake, μL/24 h	2023±144	7215±148	<0.001
Urine output, μL/24 h	920±114	5391±191	<0.001
Urinary sodium concentration, mmol/L	33.6±3.4	12.8±2.0	0.001
Urinary sodium, μmol/24 h	31.2±4.9	70.3±11.2	0.013
Fecal sodium, μmol/24 h	8.5±0.6	30.8±2.3	<0.001
Blood pressure, mm Hg	98.4±3.5	82.6±2.4	0.014
Plasma aldosterone, pg/mL	982.0±157.7	17 587.5±3477.0	<0.001

Data are presented as the mean±SEM. IEC‐MR‐KO indicates intestinal epithelial cell–specific mineralocorticoid receptor knockout.