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. 2018 Jun 29;7(13):e008950. doi: 10.1161/JAHA.118.008950

Figure 5.

Figure 5

Endogenous estrogens prevent hypertension and medial remodeling in estrogen receptor α mutated at cysteine 451 (ERα‐C451A) mice but not in ERα‐AF20 mice. A, Intact female mice were implanted with osmotic minipumps delivering angiotensin II (AngII; 0.5 mg/kg per day, 1 month). Mean of systolic blood pressure (SBP) measurements for 5 days was represented as weekly evolution of blood pressure pre‐AngII treatment (week 0) and post‐AngII treatment (weeks 1–4). SBP measurements (B through D) and and medial remodeling (E through G) from thoracic aorta were evaluated in ERα−/− (n=8; B and E), ERα‐AF20 (n=7; C and F), ERα‐C451A (n=7; D and G) intact mice and their respective littermate controls (n=7). WT indicates wild type.