Table 2.

Brain regions where significantly greater pain-related activation was seen in LowP compared to HighP groups.

Region	Max Z Statistic	Side	MNI Co-ordinates
			x	y	z
M1*	3.34	Bilateral	2	−44	58
S1	3.49	R	34	−30	54
Superior frontal gyrus	3.28	L	−24	2	52
Middle frontal gyrus	3.21	L	−54	8	38
Inferior frontal gyrus	3.56	L	−54	14	18
Anterior Insula	3.27	L	−30	20	8
Putamen	2.93	L	−26	14	6
Thalamus	3.20	L	−14	−24	10
Thalamus	3.39	R	8	−20	0
Amygdala	2.45	L	−16	−10	−10

Results are expressed as peak z scores derived from a mixed-effects analysis with outlier de-weighting and a cluster threshold at Z > 2.3, p < 0.05.

M1, primary motor cortex; S1, primary somatosensory cortex.

^*Represents regions where the difference was driven by greater deactivation in HighP state.