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. 2018 Jul 23;8:271. doi: 10.3389/fonc.2018.00271

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Copyright © 2018 Baker, Sikka, Price, Boult, Lepicard, Box, Jamin, Spinks, Kramer-Marek, Leach, Eccles, Box and Robinson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Coronal whole body PET-CT images of mice bearing CAL^R and CAL^S HNSCC xenografts (arrowed) acquired 1 h post injection of ¹⁸F-FDG. The images are shown on the same PET scale of 0–10% injected dose per gram (%ID/g). Marked uptake of ¹⁸F-FDG was also observed in the heart and bladder. (B,C) A significantly higher relative uptake of ¹⁸F-FDG was determined in the CAL^R cohort compared to the CAL^S tumors. Data are the individual (B) %ID/g and (C) normalized %ID/g for each tumor (relative to the average of the CAL^S cohort), and the cohort mean ± 1 s.e.m., *p < 0.05, Student's t-test.