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. 2018 Jul 23;9:911. doi: 10.3389/fphys.2018.00911

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Copyright © 2018 Pires, Marques, Encarnação, Abrantes, Marques, Laranjo, Oliveira, Casalta-Lopes, Gonçalves, Sarmento-Ribeiro and Botelho.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of tumor growth after therapy with AA and 5-FU (A), Oxa (B) or Iri (C) alone or in combined therapy, in a WiDr tumor xenograft. Xenotransplanted animals were divided into eight groups: control group, not subjected to any treatment (n = 6); AA group, subjected to AA alone (n = 8); 5-FU group, subjected to 5-FU alone (n = 6); AA + 5-FU group, subjected to combination therapy of AA and 5-FU (n = 4); Oxa group, subjected to oxaliplatin alone (n = 6); AA + Oxa group, subjected to combination therapy of AA and Oxa (n = 6); Iri group, subjected to irinotecan alone (n = 6); and AA + Iri group, subjected to combination therapy of AA and Iri (n = 8). Tumor growth expresses the tumor volume relative to day 0. Statistically significant differences are marked with ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.