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. 2018 Jul 20;9:1645. doi: 10.3389/fimmu.2018.01645

Figure 2.

Figure 2

The digestion process of engulfed dead cells. During the engulfment of apoptotic cells, LC3-associated phagocytosis (LAP) pathway accompanied by its components and ULK1/2 complex as a canonical autophagy pathway have specific roles. The class III PI3K collection involving VPS34, Beclin-1, UVRAG, and Rubicon are also important to the localization of PI3P at the LAPosome and canonical autophagy. PI3P has two functions: the employment of the downstream autophagic/LAP machinery including ATG5, ATG7, ATG12, and ATG16L, and fixation of the NOX2 set with recruitment of Rubicon. Also, merging the lysosome and LAPosome maturation is in need of LC3-II. The cholesterol sensors such as liver X receptor, ABCA1, PPARδ, PPARγ, and PGC-1β are similarly required for anti-inflammatory impact of efferocytosis, which can result in producing anti-inflammatory modulator such as IL-10 and TGF-β.