Table 2.

Functional enrichment of genes differentially regulated by inversions and their interaction (2La, 2Rb, a × b)

Up-regulated				Down-regulated
KEGG pathway or DAVID cluster		Score	Count	KEGG pathway or DAVID cluster	Score	Count
2Rb	KEGG: metabolic pathways	4.9E-8	95	KEGG: glutathione metabolism	2.4E-3	9
	KEGG: oxidative phosphorylation	9.3E-6	23	C-type lectin	1.8	7
	KEGG: citrate cycle (TCA)	1.9E-3	9	Lipcalin/fatty acid-binding	1.44	4
	KEGG: carbon metabolism	6.1E-3	15	CHK-kinase	1.35	19
	Oxidoreductase/Cyp450	3.12	46
	Transmembrane helix	2.3	202
	4Fe-4S	2.07	9
	TCA	1.80	25
	CHK kinase	1.68	22
	Proton transporting atpase	1.66	5
	Modulation of synaptic transmission	1.64	18
	Lipid biosynthesis	1.57	8
	Glycolysis/gluconeogenesis	1.52	8
	DNA repair	1.37	12
2La	KEGG: endocytosis	4.2E-2	35	Alpha-macroglobulin	2.76	8
	Lipid recognition (ML) domain	1.94	25	Serine protease (S1)	2.53	170
	WD40 repeat	1.62	58	Circadian rhythm	2.12	9
	Amidase	1.54	5	Innate immunity/ peptidoglycan recognition protein (PGRP)	2.05	9
	Glycoside hydrolase	1.50	37	Lysozyme	1.98	7
				Sirtuin	1.80	4
				Proteolysis	1.56	20
				Cell division/cytoskeleton	1.45	8
				LDLa	1.38	10
				Sensory perception of smell	1.33	15
a × b	KEGG: glutathione metabolism	2.6E-3	7	Ribosome/translation	1.54	14
	KEGG: carbon metabolism	4.7E-3	9	Lipocalin/fatty acid-binding	1.34	3
	KEGG: TCA	1.4E-2	5
	KEGG: retinol metabolism	2.7E-2	3
	KEGG: fructose/mannose metabolism	3.5E-2	4
	GST	1.98	9
	Aminopeptidase	1.83	13
	Zymogen	1.58	7
	Carbon metabolism	1.54	10
	Metabolic process	1.42	11
	Trypsin-like serine protease	1.39	37