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PPAR agonists reduced c-jun activation in 25-OH-cholesterol treated microglia. Cells were treated with 5 μM 25-OH-cholesterol together with 10 μM 15d-PGJ2, 100 μM indomethacin or 100 μM ibuprofen for 12 hours, then processed for Western blot analyses. Antibodies against c-jun, phospho-c-jun (at serine 63) and ERK 1/2 were used in this set of experiments. Results indicated that these agents reduced 25-OH-cholesterol induced c-jun activation to various degrees.
