Fig. 3.

Insulin sensitivity is decreased in circadian misalignment. EGP suppression during low and high insulin infusion steady state is depicted in A. Insulin-stimulated glucose disposal is expressed as R_d low insulin − R_d basal (A) and R_d high insulin − R_d basal (B). Oxidative glucose disposal (C) and nonoxidative glucose disposal (NOGD) were corrected for basal values. All values were calculated for the last 30 min of the basal, low, and high insulin steady states. Data are mean ± SEM. R_d, rate of disappearance. *P < 0.05.