Fig. 1.

Timing of the peak of the 24-h rhythm (acrophase) during constant routine following the day-shift condition and following the night-shift condition in 27 metabolites with significant 24-h rhythmicity for both conditions (Bottom Left), in 19 metabolites with significant 24-h rhythmicity for the day-shift condition only (Top), and in 19 metabolites with significant 24-h rhythmicity for the night-shift condition only (Right). Time is indicated as clock time in hours (0 = midnight). Red: metabolites. Black: timing of melatonin onset (DLMO) and timing of cortisol peak (for reference). The dashed diagonal line indicates where metabolites would fall if the timing of their rhythmicity during constant routine was unperturbed by the night-shift condition relative to the day-shift condition.