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. 2018 Jun 18;115(30):7819–7824. doi: 10.1073/pnas.1801050115

Fig. 4.

Fig. 4.

Glucose handling is improved in ARGKO mice on HFD. Experiments were performed in 16-wk-old mice that have been on HFD for 8 wk; 12 mice per group were used unless indicated otherwise. (A) Body weight. (B–F) (B and C) Blood glucose (B) and insulin (C) after food withdrawal. (D) Glucose tolerance test (GTT) after 6-h fast. (E) Insulin levels before and during GTT. (F) Insulin tolerance test after 3-h fast. (G–P) Eight animals per group were used. (G–K) Biological parameters during 2-deoxy-d-glucose uptake experiment performed after 6-h fast. (G) Body weight. (H) Blood glucose. (I) Plasma insulin. (J and K) Radioactive glucose tracer decay in plasma (J) and area under the curve (K). (L) Tissue-specific glucose uptake measured in 6-h fasted animals or during the clamp. (M–P) Biological parameters during hyperinsulinemic-euglycemic clamp. (M) Body weight. (N) Plasma insulin. (O) Glucose infusion rate. (P) Glucose disposal rate. The data are presented as mean ± SEM; *P < 0.05.