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. 2018 Jul 10;115(30):E7184–E7192. doi: 10.1073/pnas.1720493115

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Fig. 3. — AP elicited [Na⁺]_i elevations in control and Na_v1.6-cKO neurons. (A) [Na⁺]_i elevations elicited in AIS of the control (Upper traces) and cKO (Lower traces) cells by a single AP. (B) [Na⁺]_i changes associated with a train of five spikes elicited by current pulses at 20 Hz. Note that the magnitudes, spatial distributions, and time courses of the changes were similar for control and cKO neurons. Colors of traces indicate regions of interest in apical dendrite, soma, and AIS. (C) The mean peak amplitude of the AIS Na⁺ transients evoked by a single AP does not differ between the control (n = 11) and cKO (n = 14) neurons (P > 0.05).