Fig. 6.

Kinetics of use-dependent attenuation of the AIS Na⁺ fluxes is not affected by the Na_v1.6 deletion. (A) Representative recordings of changes in AIS [Na⁺]_i during a train of five APs at a frequency of 20 Hz in control (Upper) and cKO (Lower) mice. Arrows indicate the change induced by each AP. (B) Quantification of the rise in [Na⁺]_i associated with the AP train. Plotted are the values at the time of each AP in control (black, n = 9) and cKO (red, n = 9) mice. (C) The increment in [Na⁺]_i induced by each AP in the train in control (black) and cKO (red) mice.