Figure 2.

More proteinuria reduction, lower residual proteinuria, and lower proteinuria exposure over time are associated with lower renal risk. Risk on the composite renal end point with Kaplan–Meier analysis and hazard ratios calculated with the Cox proportional hazard model¹ for (A) initial proteinuria reduction, (B) residual proteinuria, and (C) exposure to proteinuria over time.¹ Initial proteinuria reduction was adjusted for age, sex, CKD diagnosis, baseline ambulatory mean arterial pressure (MAP), baseline eGFR, baseline proteinuria, and change in ambulatory MAP. Residual proteinuria was adjusted for age, sex, CKD diagnosis, baseline ambulatory MAP, baseline eGFR, and change in ambulatory MAP. Long-term exposure to proteinuria was adjusted for age, sex, CKD diagnosis, baseline ambulatory MAP, baseline eGFR, and change in ambulatory MAP. PCR, protein-to-creatinine ratio.