Table 1.
Population characteristics (on the basis of proteinuria reduction divided into three categories)
| Variable | Total ESCAPE Trial Population, n=385 | Population Selected for This Analysis, n=280 | P Valuea | |||
|---|---|---|---|---|---|---|
| Total Study Population, n=280 | Proteinuria Reduction >60%, n=92 | Proteinuria Reduction 30%–60%, n=76 | Proteinuria Reduction <30%, n=112 | |||
| Boys, n | 230 (60) | 167 (60) | 54 (59) | 49 (64) | 64 (57) | 0.59 |
| Age, yr | 11.6 (4.0) | 11.7 (3.9) | 10.9 (3.8) | 12.4 (3.9) | 11.5 (3.8) | 0.04 |
| Conventional treatment arm, n | 195 (51) | 140 (50) | 41 (45) | 40 (53) | 59 (53) | 0.45 |
| Renal diagnosis, n | 0.44 | |||||
| Glomerulopathies | 51 (13) | 36 (13) | 14 (15) | 10 (13) | 12 (11) | |
| CAKUT | 267 (70) | 199 (71) | 60 (65) | 58 (76) | 81 (72) | |
| Other | 66 (17) | 45 (16) | 18 (20) | 8 (11) | 19 (17) | |
| ACE polymorphism, n | 0.29 | |||||
| II genotype | 70 (20) | 52 (19) | 23 (25) | 12 (16) | 17 (16) | |
| ID genotype | 184 (59) | 139 (52) | 44 (48) | 43 (58) | 52 (55) | |
| DD genotype | 103 (29) | 79 (29) | 25 (27) | 19 (26) | 35 (34) | |
| Reached end point, n | 133 (36) | 80 (29) | 17 (18) | 22 (29) | 41 (37) | 0.27 |
| Baseline eGFR, ml/min per 1.73 m2 | 44 (29–59) | 46 (33–59) | 50 (37–61) | 43 (28–55) | 45 (31–60) | 0.06 |
| Baseline urinary protein-to-creatinine ratio, mg/mg | 0.9 (0.3–2.0) | 0.8 (0.3–1.8) | 1.0 (0.4–2.3) | 1.0 (0.4–1.8) | 0.6 (0.2–1.5) | 0.001 |
| Baseline serum urea, mmol/L | 13.1 (6.5) | 12.8 (6.1) | 12.1 (5.7) | 13.5 (6.1) | 13.0 (6.5) | 0.44 |
| Baseline ambulatory MAP, SDS | 1.2 (0.2–2.3) | 1.2 (0.2–2.3) | 1.3 (0.4–2.1) | 1.0 (0.2–2.2) | 1.1 (0.2–2.4) | 0.97 |
| Ambulatory MAP reduction, SDS | 1.2 (0.3–2.1) | 1.2 (0.4–2.1) | 1.4 (0.5–2.2) | 1.2 (0.6–2.0) | 1.1 (0.1–2.1) | 0.12 |
Values for continuous variables are described as mean±SD or median (25th–75th percentile); values for categorical variables as number (percentage). ESCAPE, Effect of Strict Blood Pressure Control and ACE inhibition on the Progression of CRF in Pediatric Patients; CAKUT, congenital anomalies of the kidney and urinary tract; ACE, angiotensin-converting enzyme; MAP, mean arterial pressure; SDS, standard deviation score.
a
P value for difference among the three strata of proteinuria reduction.