Table 2.
Adjusted Cox proportional hazards model with association between initial proteinuria reduction and composite renal end point
| Variable | Hazard Ratio | 95% Confidence Interval | P Value |
|---|---|---|---|
| Proteinuria reduction, % | |||
| <30 | 1.00 (reference group) | 0.40 to 1.22 | 0.21 |
| 30–60 | 0.70 | 0.22 to 0.79 | <0.01 |
| >60 | 0.42 | ||
| Boys | 0.77 | 0.47 to 1.25 | 0.29 |
| Age, yr | 1.08 | 1.02 to 1.15 | 0.01 |
| Baseline ambulatory MAP, SDS | 1.18 | 1.00 to 1.38 | 0.05 |
| Diagnosis group | |||
| Glomerulopathies | 1.00 (reference group) | 0.31 to 1.05 | 0.07 |
| CAKUT | 0.57 | 0.38 to 1.89 | 0.69 |
| Other | 0.85 | ||
| Baseline eGFR, ml/min per 1.73 m2 | 0.93 | 0.91 to 0.94 | <0.001 |
| Baseline urinary protein-to-creatinine ratio, mg/mg | 1.21 | 1.09 to 1.34 | <0.001 |
| Ambulatory MAP reduction, SDS | 0.92 | 0.77 to 1.10 | 0.39 |
No interaction was detected between proteinuria reduction and baseline proteinuria when added to the model (P=0.12). All model parameters are shown in Supplemental Table 2. No interaction was detected between proteinuria reduction and BP reduction when added to the model (P=0.10). All model parameters are shown in Supplemental Table 3. MAP, mean arterial pressure; SDS, standard deviation score; CAKUT, congenital anomalies of the kidney and urinary tract.