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. 2018 Jun 1;29(8):2234–2243. doi: 10.1681/ASN.2018020184

Table 3.

C5b9 formation on resting and ADP-activated human microvascular endothelial cells of dermal origin when incubated with follow-up serum samples from patients with hypertension-associated thrombotic microangiopathy

No. Hb, mmol/L LDH, U/L Platelets, ×109/L Creatinine, μmol/L C5b9 formation on HMEC-1, % of the control
Resting Activated
Eculizumab treatment
 2 7.2 135 199 297 21a ND
 5 5.5 143 492 ESRD 0a 0a
 6 6.3 154 298 243 17a 14a
 9 5.5 179 291 315 0a 24a
 11 6.8 138 216 132 8a 29a
No treatment
 8 7.0 239 333 ND 160 231a
 11 6.8 197 174 205 163 293a
 12 6.1 181 232 220 87 171a
 14 7.5 ND 198 98 116 248a

Hb, hemoglobin; LDH, lactate dehydrogenase; HMEC-1, human microvascular endothelial cells of dermal origin; ND, not determined.

a

P value <0.05 versus control serum run in parallel.