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. 2018 Jul 23;9:1636. doi: 10.3389/fimmu.2018.01636

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Copyright © 2018 Tarique, Naz, Kurra, Saini, Naqvi, Rai, Suhail, Khanna, Rao and Sharma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulatory effect of regulatory B cells (Bregs) on Tregs (CD4⁺CD25⁺). (A,B) Flowcytometric and graph plot representations of CD4⁺CD25⁺ T cells expressing FoxP3. Bregs (CD19⁺IL-10⁺) derived from [HCs, borderline tuberculoid (BT) and BL/LL, n = 10] were cocultured with Tregs (CD4⁺CD25⁺) derived from HCs (n = 10) and Tregs were studied by flow cytometry. (C–G) mRNA expression of FoxP3, inhibitory molecules (PD-1, CTLA-4), TGF-β, and IL-10 in Tregs (CD4⁺CD25⁺) cocultured with Bregs isolated from HCs, BT, and BL/LL (n = 10). Mean ± SD values are shown in each set while p value < 0.05 was considered significant. 50,000 cells were acquired and analyzed by flow cytometry. Data analysis was performed with flowjo software. Statistical analysis was done using Student’s t-test for unpaired samples (*p < 0.05; **p < 0.005; ***p < 0.0005).