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. 2018 Jun 4;293(29):11491–11504. doi: 10.1074/jbc.RA118.001925

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© 2018 Cai et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 7. — Mutations of 14-3-3θ–binding sites on TRPM7 affects channel localization in OK cells. A, representative confocal images of cellular localization for HA–TRPM7–WT, Ser-1403 mutants, and Ser-1567 mutants expressed in OK cells for 48 h. Scale bars, 10 μm. B, quantification of the peripheral cell localization of TRPM7–WT and indicated mutants. Data sets (n = 5–11) from five independent experiments were analyzed (means ± S.D.). ****, p < 0.0001; ***, p = 0.0001; **, p = 0.0016; *, p = 0.0191; ns, not significant.