Table 2.
Number and percentage of resistant and non-wild type isolates of Aspergillus spp. to amphotericin B and four azoles.
| AMB | L-AMB | ITZ | VCZ | PCZ | ICZ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Species (n) | R (%) CBP>2 | NWT (%) | R (%) CBP>2 | NWT (%) | R (%) CBP>2 | NWT (%) ECOFFa | R (%) CBP>2 | NWT (%) ECOFFb | R (%) CBP>0.25 | NWT (%) | R (%) CBP>1/0.25# | NWT(%) ECOFFc |
| A. fumigatus (190) | 0 | NA | 0 | NA | 8 (4.2) | 45 (23.7) | 5 (2.6) | 6 (3.2) | 29 (15.3) | NA | 147 (77.4) | 34 (17.9) |
| A. lentulus (5) | 5 (100) | NA | 5 (100) | NA | 5 (100) | 5 (100) | 4 (80) | 5 (100) | 5 (100) | NA | 5 (100) | 5 (100) |
| A. felis (1) | 0 | NA | 1 (100) | NA | 1 (100) | 1 (100) | 1 (100) | 1 (100) | 0 | NA | 1 (100) | 1 (100) |
| A. thermomutatus (1) | 0 | NA | 0 | NA | 1 (100) | 1 (100) | 1 (100) | 1 (100) | 1 (100) | NA | 1 (100) | 1 (100) |
| A. flavus/A. oryzae (14) | 5 (35.7) | NA | 6 (42.9) | NA | 2 (14.3) | 7 (50) | 2 (14.3) | 2 (14.3) | 9 (64.3) | NA | 14 (100) | 12 (85.7) |
| A. welwitschiae (7) | 0 | NA | 0 | NA | 3 (42.9) | 5 (71.4) | 0 | 0 | 5 (71.4) | NA | 7 (100) | 5 (71.4) |
| A. niger (1) | 0 | NA | 0 | NA | 0 | 0 | 0 | 0 | 1 (100) | NA | 1 (100) | 0 |
| A. terreus (4) | 4 (100) | NA | 4 (100) | NA | 0 | 0 | 0 | 0 | 0 | NA | 4 (100) | 4 (100) |
| A. pseudodeflectus (2) | 0 | NA | 0 | NA | 2 (100) | 2 (100) | 2 (100) | 2 (100) | 2 (100) | NA | 2 (100) | 2 (100) |
| A. nidulans (1) | 0 | NA | 0 | NA | 0 | 0 | 0 | 0 | 1 (100) | NA | 1# (100) | 1 (100) |
| A. sydowii (1) | 0 | NA | 0 | NA | 1 (100) | 1 (100) | 0 | 0 | 1 (100) | NA | 1 (100) | 1 (100) |
R, Resistant; NWT, non-wild type; NA, not applicable. AMB, amphotericin B; L-AMB, liposomal amphotericin B; ITZ, itraconazole; VCZ, voriconazole; PCZ, posaconazole; ICZ, isavuconazole. CBP and ECOFF units—mg/L.
a
ECOFF values for A. niger−4, A. terreus−0.5, A. fumigatus and other species−1.
b
ECOFF values for A. flavus, A. terreus and A. niger−2, A. fumigatus and other species−1.
c
ECOFF values for A. niger−4, A. terreus−1, A. nidulans−0.25, A. fumigatus and other species−2.