Table 1.
Serum pharmacokinetic of single oral dosing (2 mg and 8 mg/kg) of CBD oil in dogs.
| Cmax (ng/mL) | Tmax (h) | T1/2 elim (h) | AUC 0-t (ng-hr/mL) | MRT (h) | |
|---|---|---|---|---|---|
| DOSE (2 mg/kg) | |||||
| Dog 1 | 61 | 1 | 4.4 | 183 | 6.0 |
| Dog 2 | 132 | 1 | 3.9 | 351 | 4.2 |
| Dog 3 | 102 | 2 | 3.8 | 382 | 5.1 |
| Dog 4 | 101 | 2 | 6.8 | 437 | 9.1 |
| Median (Range) | 102 (61–132.0) | 1.5 (1.0–2.0) | 4.2 (3.8–6.8) | 367 (183–437) | 5.6 (4.2–9.1) |
| DOSE (8 mg/kg) | |||||
| Dog 1 | 499 | 2 | 3.8 | 2,928 | 5.7 |
| Dog 2 | 389 | 1 | 4.8 | 1,753 | 7.0 |
| Dog 3 | 905 | 2 | 4.2 | 3,048 | 5.1 |
| Dog 4 | 682 | 2 | 4.1 | 2,389 | 5.2 |
| Median (Range) | 591 (389–905) | 2.0 (1.0–2.0) | 4.2 (3.8–4.8) | 2,658 (1,753–3,048) | 5.6 (5.1–7.0) |
Cmax, maximum concentration; Tmax, time of maximum concentration; T1/2 el, half-life of elimination; AUC 0-t, area under the curve (time 0–24 h); MRT, median residence time.