Figure 3.

Analgesic effect of puerarin on thermal hyperalgesia in rats with peripheral nerve injury.

(A) Thermal hyperalgesia in rats treated with or without puerarin (intraperitoneally, 30 or 60 mg/kg) after pSNL. (B) Maximal efficiency (%) and ratio of response size of thermal hyperalgesia in rats at 7 days after pSNL and after 7-days puerarin treatment compared with no puerarin treatment. †P < 0.05, ††P < 0.01, vs. pSNL group (mean ± SEM, n = 7; repeated measures analysis of variance followed by least significant difference post hoc test); ##P < 0.01, vs. pSNL + puerarin 1 group at the same time point (mean ± SEM, n = 7). Statistical analysis was performed with repeated measures analysis of variance followed by least significant difference post hoc test (A) or one-way analysis of variance followed by Bonferroni correction (B). pSNL: Partial sciatic nerve ligation.