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. 2018 May 5;23(5):1095. doi: 10.3390/molecules23051095

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Anticancer activities of kaempferol on OVCAR-3 cells. (A) The effects of keampferol on the viability of OVCAR-3 cells. * P < 0.05 compared with the control group. (B,C) Flow cytometry assay revealed that kaempferol induced G2/M cell cycle arrest in OVCAR-3 cells. (D) Kaempferol influenced the expression of cell cycle-related proteins in OVCAR-3 cells. (E,F) Flow Cytometry assay presented that kaempferol induced apoptosis in OVCAR-3 cells. N, LA, L, and EA are short for necrotic cells, late apoptotic cells, living cells and early apoptotic cells. (G) Kaempferol enhanced the activity of Caspase-3/7, -8 and -9 in OVCAR-3 cells. (H) Kaempferol promoted the expression of Fas, DR5, and cleaved PARP-1 in OVCAR-3 cells.