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. 2018 Aug 1;9(4):685–695. doi: 10.14336/AD.2017.0927

Figure 2. Effects of the combined treatment with GBC and TH on the tight junction proteins, inflammatory response and cleaved-Caspase 3.

Figure 2.

The effects of GBC and TH on the expressions of Zo-1, Occludin, p-IºBα, p-NF-ºB P65, iNOS, Cox-2, and Cleaved Caspase 3 in the rat brains 8 hours post-injury. (A, C, G) Representative protein bands and densitometry data (B, D, E, F, H) from Western blots. β-actin was used as the loading control. n=5. The values are expressed as the means ± the SDs. *P<0.05 compared with sham; #P<0.05 compared with vehicle; and §P<0.05 compared to GBC+TH. GBC, glibenclamide; TH, therapeutic hypothermia; ZO-1, Zonula occludens-1.