. 2018 Aug 1;9(4):685–695. doi: 10.14336/AD.2017.0927

Table 1.

Effects of hypothermia and gbc on cerebral blood flow, blood glucose, brain and rectal temperature.

Parameters	Time points	Sham	Vehicle	GBC	TH	GBC+TH
CBF reduction (%)	Baseline (-15 min)	100.0 ± 4.3	100.0 ± 4.1	100.0 ±16.9	100.0 ±11.5	100.0± 23.5
	0 min	98.9 ± 7.4	20.6 ± 6.8^*	19.1 ± 7.5	21.7 ± 4.7	20.2 ± 4.7
	45 min	99.2 ± 5.8	16.4 ± 2..5^*	16.8 ± 2.0	17.1 ± 1.3	16.4 ± 4.0
	315 min	100.0± 5.3	86.0 ± 4.4^*	91.8 ± 3.0	104.2 ± 9.8	95.1 ± 19.1
Glucose (mg/dl)	Baseline (-30 min)	143.7 ± 5.7	145.5 ± 8.1	138.3± 13.7	147.9± 20.6	137.72 ± 19.1
	0 min	144.6 ± 8.3	165.9±14.9^*	161.4 ± 7.0^*	160.2± 47.5^*	161.7± 37.87^*
	60 min	136.5 ± 10.6	137.6 ± 23.8	138.3± 14.2	134.4± 18.4	142.5 ± 28.4
	300 min	139.8 ±11.8	141.3 ± 34.4	149.4 ±12.5	160.8± 27.6^*^#	174.6± 30.0^*^#
	480 min	141.6 ± 9.2	141.4 ± 22.2	130.2 ± 5.9	171.0± 38.0^*^#	196.0 ± 36.4^*^#
Brain temperature (°C)	Baseline (-30 min)	33.1 ± 0.5	33.1 ± 0.2	33.1 ± 0.2	33.3 ± 0.3	34.0 ± 0.5
	0 min	33.2 ± 0.2	33.2 ± 0.2	33.5 ± 0.3	33.2 ± 0.4	33.6 ± 0.5
	60 min	34.9 ± 0.3	35.2 ± 0.2	35.1 ± 0.2	31.6 ± 0.2^*^#	31.9 ± 0.5^*^#
	315 min	36.5 ± 0.4	36.8 ± 0.4	36.2 ± 0.5	32.3 ± 0.3^*^#	32.6 ± 0.3^*^#
Rectal temperature (°C)	Baseline (-30 min)	36.7 ± 0.3	36.8 ± 0.2	36.8 ± 0.2	36.8 ± 0.2	37.0 ± 0.2
	0 min	37.0 ± 0.3	37.0 ± 0.4	37.0 ± 0.5	36.7 ± 0.2	37.2 ± 0.3
	60 min	37.5 ± 0.5	37.7 ± 0.7	37.5 ± 0.2	34.5 ± 0.3^*^#	34.0 ± 0.3^*^#
	315 min	38.3 ± 0.2	39.0 ± 0.4	39.2 ± 0.3	35.3 ± 0.3^*^#	35.3 ± 0.3^*^#

The values are expressed as mean ± SD. Statistical significance was determined by a one-way ANOVA with Bonferroni correction.

P < 0.05 versus sham group.

P < 0.05 versus vehicle group using between group comparisons with Bonferroni correction. CBF, cerebral blood flow; GBC, glibenclamide; TH, therapeutic hypothermia.