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. 2018 Aug 1;9(4):578–589. doi: 10.14336/AD.2017.0817

Figure 1. Changes of body temperature during hypothermia procedure in rat after MCAO.

Figure 1

The figure shows changes in rectal temperature after reperfusion (0-180 min) for different therapies in MCAO groups, including L-DHC (0.5 mg/kg), H-DHC (1.5 mg/kg), ice pad, L-DHC combined with ice pad, and L-DHC with normal temperature group. The baseline temperatures were measured immediately after reperfusion, and all therapies were initiated after recording the baseline temperatures. No statistical differences were observed in baseline temperatures, target temperatures or endpoint temperatures in all these groups. In the combination therapy group, rectal temperature was reduced from 37.7 ± 0.07 °C to 31 ± 0.15 °C in less than 40 minutes. Ice pad rapidly reduced temperature from 37.6 ± 0.10 °C to 31 ± 0.09 °C after 50 minutes. The time for low and high DHC monotherapies to reach 31? were 180 and 120 min, respectively.