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. 2018 Jul 30;8:11399. doi: 10.1038/s41598-018-29838-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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T2-weighted MR images of two representative patients with cervical cancer during the course of concurrent chemoradiotherapy (CCRT). (A–D) a 46-year-old woman with cervical cancer (the international federation of gynecology and obstetrics FIGO stage, IIB) who had recurrence 8 months after CCRT completed. (E-H) a 59-year-old woman with cervical cancer (FIGO stage, IIIB) who maintained complete response during follow-up. (A,E) before CCRT, tumor of the recurrence case is smaller than tumor of the nonrecurrence case; (B,F) 2 weeks after CCRT initiated, tumor shows a significant decrease in size in both cases; (C,G) 4 weeks after CCRT initiated, tumor continues to shrink in both cases; (D,H) one month after CCRT completion, no obvious residual lesions could be seen on T2w images of both cases. Those two representative cases illustrate the difficulty of predicting cervical cancer recurrence for clinicians.