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. 2018 Jul 30;9:2968. doi: 10.1038/s41467-018-04389-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Effect of EP overexpression on cerebral Aβ accumulation. ELISA for measurement of Aβ40 (a, c) and Aβ42 (b, d) in the entorhinal cortex of Tg mAPP and Tg Sh3gl2/mAPP mice at the age of 5–5.5 months. EUK-134 (EUK, 2 mg/kg) (c, d) or SB203580 (SB, 0.5 mg/kg) (c, d) was administered to Tg Sh3gl2/mAPP mice once a day for 3 weeks and then cortical tissues were subjected to Aβ measurement at the age of 5–5.5 months. Date are shown as mean ± s.e.m., n = 3–6 per group (one-way ANOVA in a–d). Quantification of immunoreactive bands for Aβ (e), BACE1 (g), or IDE (i) in the indicated Tg mice at the age of 5–5.5 months. Quantification of immunoreactive bands for Aβ (f), BACE1 (h), or IDE (j) in Tg Sh3gl2.mAPP mice treated with EUK or P38 inhibitor (SB) relative to vehicle treatment. β-Actin was used as a protein loading control. Lower panels are representative immunoblots for the indicated proteins in the indicated Tg mice. Date are shown as mean ± s.e.m., n = 3 per group (one-way ANOVA in e–j)