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. 2018 Jul 30;9:2968. doi: 10.1038/s41467-018-04389-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Effect of EP overexpression on synaptic plasticity and spatial learning and memory in transgenic Tg Sh3gl2/ mAPP mice. a Tg Sh3gl2 or mAPP at 5–6 months of age do not alter hippocampal LTP, but the hippocampal LTP is significantly reduced in Tg Sh3gl2/mAPP mice as compared with non-Tg mice. Error bars represent s.e.m., n = 7–10 per group; *p < 0.01 (one-way ANOVA). Upper panel shows representative traces of fEPSP in the indicated slices before θ-burst stimulation (black line) and after 1 h (gray line). b–e Mice were tested in Morris water maze at the age of 5–5.5 months. b Escape latencies in hidden platform during Morris water maze task training in indicated groups of mice. Error bars represent s.e.m., n = 8–9 mice per group (one-way ANOVA in b). c Time spent in the quadrant with the hidden platform and d mean number of crossings of the target during the probe test. e The representative searching traces during the probe test. Data are shown as mean ± s.e.m., n = 8–9 mice per group (one-way ANOVA in c, d)