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. 2018 Jul 30;9:2981. doi: 10.1038/s41467-018-05366-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Injection of larger number of cancer cells enhances bone metastasis development. a Fluorescence microscopic analysis of cancer cells in bone marrow of the femur. Representative fluorescence images of the femur (left) and fluorescent intensities of cancer cells (right) at 30 min after CA injection of green-fluorescently labeled LLC/luc cells (2.0 × 10⁵ or 1.0 × 10⁶ cells). Cells were stained with Hoechst dyes (blue). White-dashed lines indicate growth plates. A scar bar is 200 μm. n = 4, *P < 0.05 (two-side student’s t-test). b Development of bone metastasis after injection of different number of LLC/luc cells. Representative BL images (left) and BL intensity in hind limbs (right) at 14 days after CA injection of LLC/luc cells (2.0 × 10⁵ or 1.0 × 10⁶ cells). n = 8, *P < 0.05 (two-side student’s t-test). Error bars indicate s.e.m.