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. 2018 Jul 30;8:11401. doi: 10.1038/s41598-018-29837-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of phosphosites identified using Matrigel-embedded 3D-cultured HCT116 recovered using the D and CR methods. (A) Proportional Venn diagram of phosphosites identified in all triplicate experiments from Matrigel-embedded HCT116 recovered with the D and the CR method. (B) Volcano plot of phosphosites in comparison between samples collected with the D and CR method. (blue circles: phosphosites increased in the D method samples relative to those by the CR method; red circles: phosphosites decreased in the D method samples; gray circles: phosphosites without significant differences). (C) Pathway analysis results from DAVID using significantly increased or decreased phosphosites in the samples recovered with the CR method compared to those in the samples recovered with the D method (adjusted p value < 0.05). (D) List of active kinases with significant differences by KEA (adjusted p value < 0.05).