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. 2018 Jul 30;8:11429. doi: 10.1038/s41598-018-29870-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell death induced by the combined AuNPs based photothermy and TS265. Reduction in cell viability of (A) HCT116 (B) HCT116 DOXR and (C) Fibroblasts exposed to different formulations for 4 h. The concentration of AuNPs is 8.2 nM. The concentration of NanoTS265 is 0.7 nM of nanoparticles equivalent to the IC₅₀ of TS265 free at 24 h. Irradiated cells were exposed to 3.44 W.cm⁻² for 60 s (see also Fig. S10). MTS assay was performed 24 h after irradiation. Data are the average of at least three independent assays and error bars correspondent to standard deviation.