Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jul 3;53(3):1013–1026. doi: 10.3892/ijo.2018.4467

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Dong et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Schematic diagram of exosomal lncRNA-SNHG14 in breast cancer trastuzumab resistance. In trastuzumab-resistant breast cancer cells, lncRNA-SNHG14 promotes trastuzumab resistance by targeting Bcl-2/Bax signaling, inducing the suppression of apoptotic proteins expression and inhibition of cell apoptosis. Moreover, lncRNA-SNHG14 can be packaged into exosomes and secreted from trastuzumab-resistant breast cancer cells, transferring resistance to recipient-sensitive cells. SNGH14, small nucleolar RNA host gene 14; lncRNA, long non-coding RNA; Bcl-2, apoptosis regulator Bcl-2; Bax, apoptosis regulator BAX; HER-2, human epidermal growth factor receptor 2; Casp 3, caspase-3; c-PARP, cleaved poly(ADP-ribose) polymerase.