Table 4.
Histological grading of ferric iron overload in non-tumor liver parenchyma from both Peruvian patients with hepatocellular carcinoma and comparative individuals.
| Iron overload grade | Occurrence in Patient Group (n) | Percentage in Patient Group (%) | Occurrence in Comparative Group (n) | Percentage in Comparative Group (%) |
|---|---|---|---|---|
| Grade 0 | 25 | 50 | 45 | 60 |
| Grade 1+ | 9 | 18 | 9 | 12 |
| Grade 2+ | 8 | 16 | 11 | 14.7 |
| Grade 3+ | 6 | 12 | 6 | 8 |
| Grade 4+ | 2 | 4 | 4 | 5.3 |
| Total | 50 | 100 | 75 | 100 |
Ferric iron accumulation was graded using the system established by LeSage and colleagues55. Grade 0, no stainable iron; Grade 1+, less than 25% of hepatic cells positive; Grade 2+, between 25% and 50% of hepatic cells positive; Grade 3+, between 50% and 75% of hepatic cells positive; Grade 4+, more than 75% of hepatic cells positive.