Table 2.
Hallmark pathways enriched for DE genes and genes expressed in different proportions of samples across the P to LS phases.
| GeneSet | N | n | P-value | adjusted P | |
|---|---|---|---|---|---|
| DE Genes | hallmark epithelial mesenchymal transition | 199 | 89 | 1.21E-62 | 5.94E-61 |
| hallmark estrogen response late | 200 | 73 | 3.52E-44 | 8.63E-43 | |
| hallmark estrogen response early | 200 | 68 | 5.63E-39 | 9.20E-38 | |
| hallmark kras signaling up | 199 | 67 | 4.01E-38 | 4.91E-37 | |
| hallmark il2 stat5 signaling | 200 | 62 | 4.69E-33 | 4.59E-32 | |
| hallmark hypoxia | 200 | 61 | 4.19E-32 | 3.42E-31 | |
| hallmark apoptosis | 161 | 50 | 3.81E-27 | 2.67E-26 | |
| hallmark xenobiotic metabolism | 200 | 54 | 9.73E-26 | 5.30E-25 | |
| hallmark e2f targets | 200 | 54 | 9.73E-26 | 5.30E-25 | |
| hallmark glycolysis | 200 | 53 | 7.15E-25 | 3.50E-24 | |
| Expressed/not expressed genes | hallmark estrogen response early | 200 | 39 | 2.33E-14 | 5.70E-13 |
| hallmark estrogen response late | 200 | 39 | 2.33E-14 | 5.70E-13 | |
| hallmark e2f targets | 200 | 38 | 1.15E-13 | 1.89E-12 | |
| hallmark kras signaling up | 199 | 36 | 2.21E-12 | 2.71E-11 | |
| hallmark epithelial mesenchymal transition | 199 | 35 | 1.00E-11 | 8.17E-11 | |
| hallmark apical junction | 199 | 35 | 1.00E-11 | 8.17E-11 | |
| hallmark myogenesis | 200 | 32 | 8.68E-10 | 6.08E-09 | |
| hallmark xenobiotic metabolism | 200 | 29 | 4.69E-08 | 2.56E-07 | |
| hallmark g2m checkpoint | 200 | 29 | 4.69E-08 | 2.56E-07 | |
| hallmark kras signaling dn | 200 | 27 | 5.55E-07 | 2.72E-06 |
N is the total number of genes in the pathway and n is the number of DE or expressed/not expressed genes in the pathway.