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. 2018 Jul 30;8:11387. doi: 10.1038/s41598-018-29757-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan-Meier analysis for the all-cause mortality between phosphate-binder users and non-users. (A) Non-adjusted curve. (B) Multivariable-adjusted curve. Log-rank test was used to compare the survival curve between the two groups in non-adjusted curve. Adjustment using Cox proportional hazard model was performed for baseline characteristics (age, sex, presence of diabetes mellitus and comorbidity, dialysis vintage, dialysis time per session, Kt/V for urea, normalized protein catabolic rate, body mass index, cardiothoracic ratio, systolic blood pressure, blood hemoglobin level, serum levels of urea nitrogen, creatinine, albumin, total cholesterol, C-reactive protein, corrected calcium, phosphate, parathyroid hormone, alkaline phosphatase, and use of erythropoiesis stimulating agents, anti-hypertensives, and vitamin D receptor activators. The relative hazards risk and 95%Ci in patients without P-binders compared with those with P-binders were described in the figure. A two-tailed P-value < 0.05 was considered to be statistically significant. Abbreviations: CI, confidence interval; HR, hazard ratio; P, phosphate.