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. 2018 Jun 27;53(3):1149–1159. doi: 10.3892/ijo.2018.4457

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Copyright: © Fratangelo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Inhibitory effect of ABT-888 on the invasion of melanoma cells on Matrigel. The A375 or A375R cells exposed to diluents (none) or 5 µM ABT-888 for 24 h were re-suspended in serum-free medium and seeded on polymerized Matrigel in Boyden chambers. Cells were allowed to invade the Matrigel toward 10% FBS for 18 h. For quantitative analysis of cell invasion, the value assessed in the absence of FBS (control; CTRL) was taken as 100% and all values were reported relative to that. Data represent the means ± SD of 3 experiments performed in triplicate. ^**P<0.001, statistically significant difference.