Figure 3.

The effects of EtNBSe-PDT in vivo.

Notes: (A) Morphological changes in mice inoculated with A-431 cells. A total of 100 μL of EtNBSe (500 μmol/L) was injected into the tumor tissue, and the experimental group was irradiated with 635 nm light (4.8 J/cm²). (B) The mean volume of tumor was calculated according to the formulation: volume = width × height × length ×0.5328. *P<0.05 versus the control group. (C) Tumor tissue sections of the control, LED, EtNBSe and EtNBSe-PDT groups were subjected to pathological examination at different times after PDT. The EtNBSe particles are indicated by red arrows. The scale bar represents 50 μm.

Abbreviations: EtNBSe, 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium; PDT, photodynamic therapy.