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. 2018 Jul 24;11:4315–4325. doi: 10.2147/OTT.S163366

Figure 6.

Figure 6

Relationship between ER stress and autophagy induced by EtNBSe-PDT in A-431 cells.

Notes: (A) A-431 cells were pretreated with 4-PBA (20 μmol/L) for 1 h in the presence or absence of EtNBSe-PDT. The expression levels of autophagy associated proteins were measured by Western blotting. (B) A-431 cells were pretreated with salubrinal (50 μmol/L) for 1 h in the presence or absence of EtNBSe-PDT. The expression levels of autophagy related proteins, such as p-PERK and p-eIF2α, were measured by Western blotting. *P<0.05 versus the control group. #P<0.05 versus the EtNBSe-PDT group. (C) Quantitative analysis of relative protein levels. Data represent the mean ± SD from three different experiments. *P<0.05 versus the control group. #P<0.05 versus the EtNBSe-PDT group. (D) Quantitative analysis of relative protein levels. Data represent the mean ± SD from three different experiments. *P<0.05 versus the control group. #P<0.05 versus the EtNBSe-PDT group.

Abbreviations: eIF, eukaryotic translation initiation factor; ER, endoplasmic reticulum; EtNBSe, 5-ethylamino-9-diethylaminobenzo[a]phenoselenazinium; p, phospho; PDT, photodynamic therapy; PERK, protein kinase R-like ER kinase.