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. Author manuscript; available in PMC: 2019 Jul 15.
Published in final edited form as: Cancer Res. 2018 May 7;78(14):4086–4096. doi: 10.1158/0008-5472.CAN-17-2900

Table 3.

Effects of zygosity by individual HLA Class I and Class II loci, for DLBCL, MZL, FL, and CLL/SLL (analyses adjusted for sex,age, study/region, and ancestry/principal components).

Controls
(n=6912)		 DLBCL
(n=3617)		 Controls
(n=7880)		 FL
(n=2686)		 Controls
(n=5991)		 MZL*
(n=741)		 Controls
(n=7441)		 CLL/SLL
(n=2878)
n % n % OR (95% CI) n % n % OR (95% CI) n % n % OR (95% CI) n % n % OR (95% CI)
Class I locus
HLA-B HLA-C
Heterogyzote Heterozygote 6133 89 3127 87 1.00 (ref) 6992 89 2350 88 1.00 (ref) 5321 89 637 86 1.00 (ref) 6608 89 2520 88 1.00 (ref)
Heterogyzote Homozygote 297 4 170 5 1.07 (0.83–1.36) 338 4 119 4 1.01 (0.79–1.29) 255 4 38 5 1.28 (0.89–1.85) 308 4 135 5 1.19 (0.94–1.50)
Homozygote Heterozygote 100 1 53 1 0.89 (0.58–1.38) 115 1 33 1 0.81 (0.51–1.28) 89 1 14 2 1.27 (0.70–2.30) 106 1 55 2 1.10 (0.75–1.62)
Homozygote Homozygote 376 5 265 7 1.31 (1.06–1.60) 429 5 183 7 1.23 (1.00–1.52) 322 5 52 7 1.38 (1.01–1.90) 413 6 166 6 1.04 (0.84–1.29)
p-trend 0.02 0.1258 0.02 0.43
p-trend OR 1.08 (1.01–1.15) 1.05 (0.99–1.13) 1.12 (1.02–1.24) 1.03 (0.96–1.10)
Class II locus
HLA-DPB1 HLA-DQB1 HLA-DRB1
Heterozygote Heterozygote Heterozygote 4889 72 2341 65 1.00 (ref) 5545 71 1694 63 1.00 (ref) 4247 71 501 68 1.00 (ref) 5255 71 1994 70 1.00 (ref)
Heterozygote Heterozygote Homozygote 52 1 42 1 2.10 (1.24–3.55) 62 1 48 2 2.60 (1.66–4.06) 42 1 9 1 2.10 (0.99–4.45) 61 1 39 1 1.76 (1.09–2.86)
Heterozygote Homozygote Heterozygote 239 3 149 4 1.01 (0.77–1.33) 263 3 122 5 1.33 (1.03–1.73) 213 4 24 3 0.80 (0.51–1.26) 257 3 110 4 1.15 (0.88–1.49)
Heterozygote Homozygote Homozygote 345 5 277 8 1.54 (1.25–1.91) 403 5 195 7 1.42 (1.14–1.76) 297 5 48 6 1.43 (1.03–2.00) 378 5 172 6 1.12 (0.90–1.39)
Homozygote Heterozygote Heterozygote 1137 17 639 18 1.05 (0.92–1.21) 1331 17 490 18 1.21 (1.06–1.39) 986 17 126 17 1.11 (0.89–1.37) 1225 17 437 15 0.88 (0.76–1.01)
Homozygote Heterozygote Homozygote 28 0 24 1 1.44 (0.77–2.71) 30 0 13 0 1.33 (0.66–2.68) 18 0 1 0 0.62 (0.08–4.82) 26 0 13 0 1.15 (0.54–2.48)
Homozygote Homozygote Heterozygote 53 1 43 1 1.38 (0.82–2.33) 60 1 31 1 1.88 (1.14–3.10) 48 1 11 1 1.54 (0.75–3.16) 58 1 39 1 1.78 (1.11–2.85)
Homozygote Homozygote Homozygote 136 2 91 3 1.30 (0.92–1.82) 153 2 82 3 1.89 (1.37–2.61) 123 2 20 3 1.48 (0.90–2.44) 143 2 62 2 1.10 (0.77–1.57)
p-trend 0.0091 <0.0001 0.04 0.95
p-trend OR 1.04 (1.01–1.06) 1.07 (1.05–1.10) 1.04 (1.00–1.09) 1.00 (0.97–1.03)