Table 2.
GALA II DNA Methylation Analysis Results.
| GALA II Population | Probe Gene | Probe ID | rsid | Distance of SNP to Probe | Marginal p-value | AITL p-value | AITL Replication p-value |
|---|---|---|---|---|---|---|---|
| MX | CNFN | cg14327995 | rs16975986 | 280795 | 2.49E-09 | 5.69E-09 | 9.27E-03 |
| MX | C11orf95 | cg16678159 | rs7106153 | 249768 | 2.58E-01 | 2.52E-08 | 9.39E-02 |
| MX | NA | cg05697734 | rs1560919 | 13711 | 1.14E-01 | 2.21E-08 | 8.18E-03 |
| MX | TNK2 | cg01792640 | rs67217828 | 278866 | 4.49E-01 | 6.38E-09 | 1.43E-02 |
| MX | HDAC4 | cg06533788 | rs925736 | 9548 | 4.51E-01 | 3.09E-09 | 2.80E-02 |
| PR | NA | cg07436864* | rs8117083 | 31813 | 7.46E-02 | 1.34E-09 | 5.34E-03 |
| PR | NA | cg16803083* | rs4312379 | 63847 | 3.69E-01 | 2.29E-08 | 2.31E-04 |
| PR | SERPINA6 | cg10025865 | rs17091085 | 247796 | 6.83E-01 | 2.97E-08 | 8.05E-03 |
P-values for AITL applied to the methylation data in the GALA II Latinos. MX and PR denote Mexicans and Puerto Ricans respectively in the GALA II population columns. The probe gene column shows the gene that the methylation probe lies in. The marginal column is the p-value for standard linear regression of methylation on genotype while controlling for population structure.
*
indicates results that replicated between the Mexicans and Puerto Ricans.