Table 1.

Participant Inclusion/Exclusion Criteria

Inclusion criteria	Exclusion criteria
Age 65–100 years old	Active treatment for cancer, stroke (<6 months), peripheral vascular disease, coronary artery disease (myocardial infarction <6 months), stage III, IV CHF, valvular heart disease, severe anemia, liver or renal disease, diabetes, severe osteoarthritis, fracture in extremity ≤6 months, extremity amputation
BMI 25–35	CBC values and CMP values not cleared by physician
Report of ability to walk one mile	Anabolic medications or Anticholinesterase inhibitor; Anticoagulant therapy (aspirin use permitted); Statin use
MMSE >24	History of significant head injury; Vision or hearing impairment
C-reactive protein levels ≥1.0 mg/L	Dementing illness, major psychiatric disease, Parkinson's Disease
Nonsmoker	Excessive alcohol use (>2 drinks/day) or >1 glass of red wine or purple grape juice/week
	Blood pressure >180/100 mmHg; Resting heart rate >120 bpm
Sedentary lifestyle (<120 min of aerobic activity/week)	Aerobic physical activity (i.e., running, bicycling, etc.) >120 min per week
Willing and able to participate in all aspects of the study	Failure to give consent
Willing to be randomized to either treatment group	Consumption of any dietary supplements containing resveratrol, quercetin, grape seed extract, ginko biloba, or P. cuspidatum in the previous 90 days
	Participation in another clinical trial or intake of an investigational product ≤30 days before screening/enrollment
	CES-D >20; Current use of an antidepressant
	Contraindications to MRI (e.g., cardiac pacemaker, implanted cardiac defibrillator, aneurysm clip, claustrophobia, etc.)

BMI, body mass index; CBC, complete blood count; CMP, complete metabolic panel; MMSE, Mini-Mental Status Examination.