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. 2018 Jul 26;13:2255–2259. doi: 10.2147/COPD.S161958

Figure 1.

Figure 1

Transcriptome analyses and selected protein candidates in tissue microarrays.

Notes: (A) Heatmap of significantly regulated genes with 2.5-fold induction in individual tissue samples (one-way analysis of variance with Benjamini–Hochberg correction, cutoff p-value <0.05). (B) Histologic analyses of HOPE-fixed lung tissue of COPD patients. a) AQP3, b) ECM1, c) FHL1, d) MFGE8, e) PDE4DIP, and f) SLC6A8. Magnification ×200. The presence of the respective proteins of the candidate genes in the lung tissue should validate the transcriptome results and reveal the cell types expressing the proteins.

Abbreviations: AQP3, aquaporin 3; ECM1, extracellular matrix protein 1; FHL1, four and a half LIM domain 1; HOPE, HEPES-glutamic acid buffer mediated organic solvent protection effect; GOLD, Global Initiative for Chronic Obstructive Lung Disease; MFGE8, milk fat globule epidermal growth factor 8; PDE4DIP, phosphodiesterase 4D-interacting protein.