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. 2018 Jul 26;13:2255–2259. doi: 10.2147/COPD.S161958

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© 2018 Heinbockel et al. This work is published and licensed by Dove Medical Press Limited

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RNA expression levels of the candidate genes after cigarette smoke extract (CSE) stimulation.

Notes: (A) Isolated human primary pneumocytes type II and (B) primary alveolar macrophages were investigated for their induction of IL8, ECM1, FHL1, and MFGE8 after CSE exposure. This primary cell model exhibits the dependence of the candidate gene expression on CSE because cigarette smoke is the leading cause of COPD. Data from five independent samples of different donors were analyzed in duplicates. Statistical analysis was performed by using the repeated-measure one-way analysis of variance with a Bonferroni multiple comparison correction; *cutoff p-value <0.05.

Abbreviations: ECM1, extracellular matrix protein 1; FHL1, four and a half LIM domain 1; IL8, interleukin 8; MFGE8, milk fat globule epidermal growth factor 8; Unstim, unstimulated.