Table 1.
Representative CAMs and expression distribution
| CAMs | Expression distribution |
|---|---|
| Selectins | |
| E-selectin | Endothelium, activated astrocytes |
| P-selectin | Endothelium, platelets |
| L-selectin | Leukocytes |
| Integrins | |
| α5β1 | B- and T-cells, astrocytes, endothelium |
| α1β1 | Astrocytes, endothelium |
| α6β1 | T-cells, microglia, oligodendroglia endothelium |
| αvβ3 | B- and T-cells, monocytes, endothelium, microglia, oligodendroglia |
| αLβ2 | Leukocytes, macrophages, T-cells, microglia |
| αMβ2 | B-cells, NK-cells, macrophages, microglia |
| αXβ2 | Dendritic cells, B-cells, macrophages, microglia |
| Immunoglobulin superfamily | |
| ICAM-1 | Endothelium, astrocytes, microglia |
| NCAM | Neurons |
| VCAM-1 | Endothelium, monocytes |
| PECAM-1 | Endothelium, leukocytes |
| L1CAM | Neurons |
| Cadherins | |
| Classical cadherins | |
| N-cadherin | Neurons |
| E-cadherin | Endothelium, neurons |
| Protocadherins | |
| Clustered | Neurons |
| Nonclustered | Neurons |
Abbreviations: CAM, cell adhesion molecule; E-cadherin, epithelial cadherin; E-selectin, endothelial leukocyte cell adhesion molecule; ICAM-1, intercellular cell adhesion molecule 1; L1CAM, L1 cell adhesion molecule; L-selectin, leukocyte selectin; N-cadherin, neuronal cadherin; NCAM, neural cell adhesion molecule; PECAM-1, platelet endothelial cell adhesion molecule 1; P-selectin, platelet-activation-dependent granule-external protein; VCAM-1, vascular cell adhesion molecule 1.