Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Neuroprotective mode of action: MMF on Nrf2 Phase II genes activation, such as NQO1 (NAD(P)H:quinone oxidoreductase-1) and glutathione S-transferase.
Abbreviations: ARE, antioxidant-responsive element; MMF, monomethylfumarate; Nrf2, nuclear factor E2-related factor-2; Keap1, Kelch-like ECH-associating protein-1; UL, ubiquitin; Glutat, glutathione S-transferase.
