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. 2012 Jul 26;3:69–77. doi: 10.2147/RRTM.S24764

Table 2.

Medicines with doses used to treat tegumentary and visceral leishmaniasesa

Pentavalent antimonials Amphotericin B deoxycholate Liposomal amphotericin B Pentamidine isethionate Miltefosine
Localized cutaneous leishmaniasis 10–20 mg/Sb+5/kg/day (iv or im)
10–20 days		 1 mg/kg/day (iv)
Total dose: 1.0–1.5 g		 4 mg/kg/day (im)
Maximum dose: 2 g		 2.5 mg/kg (oral)
28 days to treat
L. mexicana
Disseminated cutaneous leishmaniasis 20 mg/Sb+5/kg/day (iv or im)
28 days		 1 mg/kg/day (iv)
Total dose: 1.0–1.5 g		 4 mg/kg/day (im)
Maximum dose: 2 g
Diffuse cutaneous leishmaniasis 20 mg/Sb+5/kg/day (iv or im)
28 days		 Not used Not used
Leishmaniasis recidiva cutis 15–20 mg Sb+5/kg (iv or im) per day for 28 daysb
Mucosa leishmaniasis 20 mg/Sb+5/kg/day (iv or im)
30 days		 1 mg/kg/day (iv)
Total dose: 2.0–2.5 g		 2–3 mg/kg/day (iv)
Total dose: 40–60 mg/kg		 Not used 2.5 mg/kg (oral)
28 daysc
Visceral leishmaniasis 20 mg/Sb+5/kg/day (iv or im) for 28 daysd 0.75–1.00 mg/kg/day (iv)
15–20 doses		 3–4 mg/kg/day (iv)
Total dose: 15–24 mg/kg		 Not used 2.5 mg/kg (oral)
28 dayse

Notes:

a

Doses and time of treatment were based on WHO recommendation from 2010;

b

in case of no response to the usual dose of Sb+5, Sb+5plus allopurinol 20 mg/kg for 30 days is indicated when L. tropica is the agent;

c

only in Bolivia;

d

except Bihar (Indian subcontinent);

e

only in the Indian subcontinent.

Abbreviations: Sb+5, pentavalent antimonial; iv, intravenous; im, intramuscular.